Qualia Mind Review: Still The Best Nootropic Supplement?

Qualia Mind is a nootropic supplement that can enhance cognition. It contains 28 nootropic compounds, making it one of the most advanced brain supplements. But is it effective? How about its safety? Here is an in-depth Qualia Mind review.

What Is It?

Qualia Mind is a nootropic stack developed for achieving optimal mental performance. It is classified as a dietary supplement despite its complex formulation and 28 active ingredients.

Nootropics are brain-enhancing compounds that are side-effects-free. Most nootropic supplements contain a blend of individual nootropic compounds.

Qualia Mind is one of the most trusted nootropic blends on the market. It was developed to:

1. Improve brain fog
2. Provide energy & focus
3. Boost brain nutrition and brain function
4. Increase focus and motivation
5. Help with mental clarity and flow
6. Support sustained mental focus

Qualia Mind is one of the few dietary supplements that was used in a clinical study in 2020. A randomized, double-blind, placebo-controlled, crossover study was conducted to check the efficacy of Qualia Mind on cognition in a healthy population.

This clinical study showed that Qualia Mind improved cognitive function in healthy individuals. However, this clinical trial is still ongoing to evaluate the safety and efficacy of Qualia Mind.

Because of this and other reasons, Neurohacker Collective, the company behind the product, has an outstanding reputation in the nootropic industry. They developed more than six other advanced supplements for sleep, immunity, longevity, and energy besides Qualia Mind.

Qualia Mind is one of the most expensive and complex nootropic stacks, but it is also one of the most trusted and popular. Can you expect an improvement by supplementing it? And is it safe?

Let’s dive into what makes Qualia Mind stand out.

Ingredients

Qualia Mind is a premium supplement that contains 28 active ingredients. Its complex formula makes Qualia Mind such a distinctive product on the market.

Here are the ingredients in Qualia Mind:

• 100 mg  Vitamin C
• 25 mcg Vitamin D3
• 100 mg Thiamin B1
• 50 mg Niacin B3
• 20 mg Vitamin B6
• 1000 mcg Vitamin B12
• 50 mg of Pantothenic acid
• 500 mg Acetyl-L-Carnitine
• 500 mg Artichoke stern and leaf extract
• 300 mg Bacopa monnieri
• 300 mg Rhodiola rosea root
• 300 mg DL-Phenylalanine
• 250 mg Uridine Monophosphate Disodium
• 250 mg N-Acetyl-L-Tyrosine
• 200 mg Taurine
• 200 mg L-Theanine
• 200 mg Alpha GPC
• 150 mg Cognizin
• 100 mg Mucuna pruriens seed
• 100 mg Phosphatidylserine
• 100 mg Theobromine
• 90 mg Caffeine
• 80 mg DHA
• 60 mg Celastrus paniculatus seed extract
• 50 mg Ginkgo biloba
• 20 mg Coleus forskohlii root
• 10 mg Pyrroloquinoline quinone
• 50 mcg Huperzine A

Neurohacker Collective is known for combining lots of nootropics in such advanced blends. But what exactly can those nootropics do? Are they even safe and effective at the dosages you can find in Qualia Mind?

Acetyl-L-Carnitine HCL

Acetyl-L-carnitine is an amino acid produced by the body from methionine and lysine. It is involved in the mitochondrial oxidation of long-chain fatty acids. [*]

Supplementing Acetyl-L-carnitine may be beneficial for depression and fatigue. [*][*]

Qualia Mind contains 500 mg, which is an optimal dosage.

Artichoke Stem and Leaf Extract (5% Cynarin)

Artichoke leaf extract (Cynara scolymus) has antioxidant benefits for brain health and brain function. [*] Besides, using it reduces cholesterol and improves fat digestion. [*] Artichoke may also boost blood flow to the brain. [*]

Artichoke is not a typical nootropic, but it shows some nootropic benefits.

Bacopa Monnieri Leaf Extract (45% Bacosides)

Bacopa monnieri (Brahmi) is an adaptogen herb used in traditional Ayurveda medicine. [*] Bacopa is one of the most potent nootropics for improving short-term memory. [*] It also decreases stress and anxiety. It may provide anti-inflammatory effects. [*][*]

Bacopa Monnieri is a prevalent adaptogen herb known for its cognitive-boosting properties. [*]

The most important benefit of this Ayurvedic herb is its effect on memory. Randomized, double-blind, placebo-controlled trials showed the memory benefits of Brahmi. [*]

The recommended daily dosage is 300 mg of a potent extract with 50% of the active compound bacosides. That’s precisely the dosage in Qualia Mind.

Rhodiola Rosea Root Extract (3% Rosavins, 1% Salidrosides)

Rhodiola Rosea is an adaptogen herb known for its anti-fatigue and adaptogenic properties. [*] Rhodiola Rosea enhances well-being and cognition in healthy individuals. [*] It is also beneficial for depression and anxiety. [*]

The recommended daily dosage is 50-688 mg of a quality extract with 3% rosavins and 1% salidrosides. Qualia Mind has 300 mg of Rhodiola.

DL-Phenylalanine

DL-Phenylalanine is an amino acid that improves mood and anxiety levels. [*] It has been studied for its effects on depression as well.

Phenylalanine is crucial for the production of tyrosine (dopamine precursor), dopamine, and epinephrine. [*]

One study shows that phenylalanine can help with treating depression. [*] Other studies show mixed results.

Uridine Monophosphate Disodium

Uridine 5 monophosphate heptahydrate is a nucleotide that possesses cognitive enhancing properties. [*] Studies show reduced depressive symptoms in patients with bipolar disorder. [*]

However, we lack studies on healthy individuals. The recommended daily dosage of uridine monophosphate disodium has not been established yet.

N-Acetyl L-Tyrosine

L-Tyrosine is an amino acid known for its cognitive and physical boosting properties. It also increases the production of dopamine, which is important for attention span. [*]

N-Acetyl L-Tyrosine is trendy among athletes, entrepreneurs, and students, because it improves cognitive function in stressful situations. [*] For the best effects, it is essential to supplement it before a stressful activity.  [*]

Studies show that supplementing NALT enhances cognition in animals and adults. Supplementing NALT is beneficial for people with ADHD [*], and it promotes cognitive flexibility in healthy adults. [*]

The recommended daily dosage is 500-2000 mg. Qualia Mind has 250 mg.

Taurine

Taurine is an organic acid that is important for cardiovascular function and brain development. [*] Just two weeks of taurine supplementation improved blood flow and reversed endothelial dysfunction in type 1 diabetics. [*]

Dosage between 500 mg and 2000 mg have been proven effective.

L-Theanine

L-theanine is an amino acid found in green that promotes relaxed focus. It calms people down while it increases focus and cognitive performance. [*] L-theanine increases blood flow and the production of neurotransmitters. Supplementing L-theanine increases alpha-wave activity in the brain. [*][*]

The recommended daily dosage is 100-200 mg. Qualia Mind has 200 mg of L-theanine.

Alpha GPC

Alpha GPC (Alpha-glycerophosphocholine) is a cholinergic compound that increases the acetylcholine levels in our brain. [*] Acetylcholine is a neurotransmitter that plays a vital role in mental function and is responsible for learning, focus, and memory.

Studies show that supplementing Alpha GPC may slow down cognitive decline and improve power output in adults. [*]

The recommended daily dosage is 300-600 mg. You can find 200 mg in Qualia Mind.

Citicoline (Cognizin®)

Citicoline is the generic name for CDP-choline or cytidine diphosphate choline. It is a building block of cell membranes and affects the brain’s ability to produce acetylcholine. [*]

Citicoline improves memory, circulation and protects the brain from harmful agents. [*][*]

Long term, it helps maintain healthy brain function against age-related structural changes and mental decline. Citicoline has also been suggested to assist with recovery after brain injury.

Mucuna Pruriens Seed Extract (50% L-Dopa)

Mucuna pruriens (velvet bean) is a legume used in traditional Ayurvedic and Unani medicines. The bean contains an amino acid L-DOPA, which is a direct dopamine precursor. [*] Supplementing Mucuna pruriens supports dopamine, norepinephrine, and serotonin production. [*]

It also supports healthy stress hormone levels, neuroprotection, and growth hormone levels. [*] In this study, an increase in well-being has been found secondary to a reduction of cortisol.

Phosphatidylserine (Sharp-PS® Green)

Phosphatidylserine is a compound similar to a dietary fat found in human neural tissue. Supplementing phosphatidylserine contributes to cognitive functioning, slows down cognitive decline, and improves memory. [*]

Since phosphatidylserine levels naturally decline with aging, supplementing it is beneficial.

One study shows that 300 mg of phosphatidylserine for 12 weeks significantly reduced symptoms of cognitive decline in persons with Alzheimer’s disease. [*]

In another study, people were given 300 mg of phosphatidylserine for 6 months. The scores on the rating scales associated with cognitive decline and dementia improved. [*]

The recommended daily dosage is 100 mg, taken up to 3 times. Qualia Mind contains 100 mg.

Theobromine

Theobromine is a compound that has stimulatory effects similar to caffeine. [*] Over 20 studies show that theobromine increases blood flow in healthy adults. [*] It has a stimulatory effect, but it is weaker than caffeine.

Anhydrous Caffeine (Whole Coffee Fruit Extract From Organic Coffeeberry)

Caffeine is a powerful stimulant that improves energy, physical strength, and endurance. [*] It enhances performance and ensures prolonged wakefulness. [*] It may also improve the well-being of individuals.

Habitual caffeine use is associated with a reduced risk of Alzheimer’s and liver cancer. Anhydrous caffeine is extracted from the whole coffee fruit, and it is extremely potent. That’s why it has such strong stimulant properties.

DHA (Docosahexaenoic Acid from Algae)

DHA is an anti-inflammatory fatty substance and a must-use compound for optimal brain health. [*] Studies show that supplementing DHA improves ADHD, fights inflammation, helps with eye health, and may slow down cognitive decline. [*]

The combination of DHA and EPA is crucial for the working nervous system.

Celastrus Paniculatus Extract

Celastrus paniculatus is a plant that has been used in traditional Ayurveda medicine to alleviate cognitive issues and promote intestinal health. [*]

Animal studies show that it may be beneficial for improving cognitive performance under stress. [*][*]

It contains a number of brain-supporting compounds however, we lack clinical studies to confirm its safety and efficacy in healthy individuals.

Ginkgo Biloba Leaf Extract (24%)

Ginkgo biloba is a popular herb used by the elderly to slow down cognitive decline. [*] Multiple studies confirm that supplementing Ginkgo improves cognitive and neuropsychiatric symptoms in persons with dementia. [*] Ginkgo can also improve cognition and age-related memory loss. [*]

The recommended daily dosage is 120-240 mg. Qualia Mind has 50 mg.

Coleus Forskohlii Root Extract (20% Forskolin)

Coleus Forskohlii is a herb used in traditional Ayurvedic medicine for boosting testosterone. [*] Its main bioactive ingredient, forskolin, may work as a fat burner. Other benefits include reduced fatigue, increased HDL, and improved inflammation.

Pyrroloquinoline Quinone

Pyrroloquinoline Quinone Disodium (PQQ) is a vitamin-like molecule that improves stress management, sleep, and fatigue levels while also offering significant antioxidant protection. [*] Supplementing pyrroloquinoline Quinone leads to reduced stress, fatigue, and improved sleep. [*]

The recommended daily dosage is 20-40 mg.

Huperzine A (Huperzia Serrata Leaf Extract)

Huperzine A is a cognitive enhancer extract from the Huperzia Serrata herb that inhibits an enzyme that degrades the learning neurotransmitter, acetylcholine. [*]

Supplementing Huperzine A may improve memory and slow down cognitive decline. [*]

Due to its effects on neurotransmitters, you need to cycle Huperzine-A to avoid potential side effects.

Vitamins

Besides the nootropics, Qualia Mind contains crucial vitamins for brain health.

• Vitamin C
• Vitamin D3
• Thiamine
• Niacin
• Vitamin B6
• Vitamin B12
• Pantothenic acid (Vitamin B5)

So, which benefits can you expect from Qualia Mind?

Benefits

Benefits of Qualia Mind include:

• Better focus and concentration
• Long-term brain health
• Enhanced memory & cognition
• Improved productivity
• Mental clarity
• Amplified drive & energy boost

Better Focus And Concentration

The first and most important benefit of Qualia Mind is increased focus and concentration. A mix of potent nootropics ensures that you get more focused, even during stressful activities. Sustaining attention is essential if you want to stay in the zone (flow).

Qualia Mind can improve your focus and concentration by increasing the amount of three crucial neurotransmitters – dopamine, acetylcholine, and noradrenaline.

Better Memory

Nootropics like Bacopa Monnieri, Ginkgo Biloba, Alpha GPC, and Cognizin are known memory boosters. They can improve different types of memory in healthy individuals. They can help users to think faster and recall better. Having a great memory is crucial for all active individuals, and Qualia Mind excels here.

Long-Term Brain Health

Qualia Mind contains potent antioxidant nootropics, vitamins and minerals that protect your brain from toxins and stress. In addition, certain compounds also protect your nerve cells. Qualia Mind is an outstanding supplement for people who care about their brain health.

Energy Boost

Because of the combination of caffeine, PQQ, theobromine, and l-theanine, you can expect a mild energy boost from Qualia Mind. Compared to drinking coffee, the boost is weaker, but it lasts longer and comes without side effects such as nervousness.

Many prefer the energy boost from dietary supplements to drinking coffee.

Improved Learning

Despite its high price, Qualia Mind is popular among students as well. Learning with this supplement is easier and more effective. You can stay in the flow for about 4-5 hours without any significant side effects.

But how exactly does Qualia Mind work?

My Experience

When I received Qualia Mind for the first time, I was a bit skeptical about trying it. Not because I didn’t believe it is a high-quality supplement, but I was worried about the potential side effects. With 28 ingredients in Qualia Mind, you can never be sure.

But after my careful analysis of the ingredients (more about them below), I expected a lot from it. I hoped Qualia Mind would boost my focus, energy, and cognitive function.

Here is what happened.

Test Period

I started my test by taking seven capsules per day. After a few days, I increased the recommended dosage to ten and later even twelve capsules per day. However, I soon figured out that around 7 capsules per day are an optimal dosage.

An hour after I took the capsules, I noticed increased alertness, focus, and a smooth energy boost. I felt how my mood improved, how work became easier and more fun.

My focus narrowed, and I got a slight energy boost. It seemed like working on complex tasks was easier than ever before.

Now, don’t expect a massive kick of any sort, but this pleasant boost is more than welcome every morning.

The first days on Qualia Mind were extremely fun, no doubt about that. However, since this supplement contains many nootropics that need a bit of time to provide the benefits (such as Bacopa Monnieri), you will notice a gradual improvement in your performance over weeks of supplementing Qualia Mind.

You can expect the best results after 5-6 weeks of taking this advanced nootropic stack.

So, Qualia Mind got me into a hyper-productive zone that lasted for about 4-5 hours.

But besides its effectiveness, I liked it for several other reasons:

1. The brand is like a Mercedes among cars – very premium
2. They have lots of supporters even among doctors, health and fitness experts
3. Their packaging is fabulous

2022 Update

I’ve occasionally used Qualia Mind ever since my first review. To test its efficacy, I recently supplemented Qualia Mind while playing the dual-n-back memory game.

My score improved by 7-12% on average just after one use. I am convinced that things like this happened due to a greater focus and improved attention span.

As a matter of fact, the dual-n-back game requires a very narrow focus and attention, that’s why I saw such an increase in my performance.

Is It Safe?

Formulation

Qualia Mind contains 28 well-dosed nootropic compounds. Compared to some other competitors, this supplement contains a few under-researched ingredients.

That doesn’t mean it is unsafe, but we lack information about long-term use.

Ingredients

Qualia Mind results from thousands of hours of research by top scientists who work at the Neurohacker Collective. This should give you the idea that everything that’s in the supplement has been thoroughly researched, studied extensively, and how safe the supplement is.

Based on the available data, Neurohacker Collective mostly uses quality ingredients. The fact that they use many branded ingredients such as Coznigin, Organic Coffeeberry, etc., is a compelling sign.

High Manufacturing Standards

Qualia Mind is manufactured in the US, in the GMP-compliant facility. I can confirm that Neurohacker Collective is using the highest-quality manufacturing standards.

What is also remarkable is the fact that most people working at Neurohacker Collective supplement Qualia Mind by themselves. I think that’s pretty cool and rare. It does not confirm Qualia Minds’ safety, but if a group of scientists takes their formulations, there is really not too much to be afraid of.

So, according to my research, Qualia Mind is a safe nootropic supplement for healthy people in the short term. But we need more data to prove its long-term safety.

How Does It Work?

Qualia Mind is based on complex systems science. It upregulates multiple pathways, takes advantage of nutrient synergies, and it embraces the Goldilocks zone. Some Qualia Mind compounds provide immediate physiological and neurochemical effects, while others provide long-term effects by:

• Supporting mitochondrial function
• Supporting acetylcholine signaling
• Neuron synaptic formation

All in all, Qualia Mind enhances BDNF (brain-derived neurotrophic factor), supports neuron & synaptic function, supports neurotransmitter signaling, and enhances stress resilience, and refills essential nutrients that can affect your cognition.

But is it safe for supplementation?

Side Effects

Most ingredients in Qualia Mind are considered safe for supplementation. The dosages of all ingredients, quality extracts, and high-production standards make Qualia Mind a safe supplement for supplementation.

However, some Qualia Mind nootropics may still cause adverse side effects to some users. In particular, Huperzine A is a problematic ingredient when taken long-term for more than six months. Huperzine A side effects may include: [*][*]

• Nausea
• Diarrhea
• Dry mouth
• Constipation
• Vomiting
• Fainting
• Restlessness
• Cramping
• Loss of appetite
• Dizziness
• Blurred vision
• Sweating
• Inability to sleep
• High blood pressure
• Slowed heart rate

Another problematic compound is caffeine, which can cause restlessness, insomnia, headaches, anxiety, dehydration, and rapid heart rhythm. [*]

Lastly, supplementing Gingko Biloba can lead to moderate adverse effects: [*]

• Nausea
• Muscle weakness
• Digestive problems
• Diarrhea
• Allergic skin reactions
• Headaches

Warnings

Qualia Mind contains ingredients that can interact with certain medications:

• Antidepressants;
• Anticoagulants and antiplatelet medications, including Clopidogrel (Plavix), aspirin, Ibuprofen (Advil, Motrin), Diclofenac (Voltaren, Cataflam), Naproxen (Anaprox, Naprosyn), Enoxaparin (Lovenox), Dalteparin (Fragmin), Heparin, and Warfarin (Coumadin).
• Antibiotics, including Enoxacin (Penetrex), Ciprofloxacin (Cipro), Sparfloxacin (Zagam), Norfloxacin (Chibroxin, Noroxin), Grepafloxacin (Raxar), and Trovafloxacin (Trovan);
• Drying medications (anticholinergics) including Atropine and Scopolamine;
• Ephedrine and other stimulants that speed up the nervous system;
• Medications for Alzheimer’s disease (Acetylcholinesterase (AChE) inhibitors);
• Medications used for allergies (antihistamines);
• Medications for high blood pressure, including Verapamil (Calan, Isoptin, Verelan), Nifedipine (Adalat, Procardia), Isradipine (DynaCirc), Felodipine (Plendil), Diltiazem (Cardizem), and Amlodipine (Norvasc);
• Medications that increase blood flow to the heart.

If you take any of the mentioned drugs for other health conditions, consult your doctor before supplementing Qualia Mind to avoid potential risks.